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Sebbene questo effetto sia minore, e non sia stato di alcuna rilevanza clinica, dovrebbe essere considerato quando questi medicinali sono somministrati contemporaneamente.
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Esistono dati clinici limitati sulla sicurezza del tadalafil somministrato in dose singola in pazienti con compromissione epatica grave (classe C secondo la classificazione di Child-Pugh).
Sono stati segnalati casi di improvvisa perdita dell’udito dopo l’uso di tadalafil. Sebbene in alcuni casi fossero presenti altri fattori di rischio (occur l’età, il diabete, l’ipertensione e una precedente storia di perdita di udito) i pazienti devono essere avvertiti di interrompere l’assunzione di tadalafil e consultare immediatamente un medico in caso di improvvisa riduzione o perdita dell’udito.
Using sildenafil and an α1 sikik blocker (commonly child porn prescribed for hypertension or for urologic problems, for example benign prostatic hypertrophy) simultaneously could cause small blood pressure, but this result isn't going to happen If they're taken not less than four hrs aside.[29]
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